5-[(4-methylphenyl)sulfanyl]-2,4-quinazolinediamine

**Description:**\n5-[(4-methylphenyl)sulfanyl]-2,4-quinazolinediamine is a synthetic small molecule featuring a quinazoline core with amino groups at the 2 and 4 positions and a sulfanyl group attached to a para-substituted methylphenyl ring. This structure confers potential biological activity relevant to medicinal chemistry. The compound has been studied as an experimental ligand for dihydrofolate reductase (DHFR), including in Candida albicans and other species. Its mechanism of action is presumed to involve inhibition of DHFR—a key enzyme in folate metabolism—suggesting possible antimetabolite or antimicrobial properties. However, it has not been approved for any clinical use or advanced beyond early-stage research[1][3][7].

Other names

5-(p-tolylthio)quinazoline-2,4-diamine5-(4-tolylthio)-2,4-diaminoquinazoline5-(4-methylphenyl)sulfanylquinazoline-2,4-diamine5-[p-tolylthio]quinazoline-2,4-diamine5-[p-methylphenylthio]quinazoline-2,4-diamine